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Dataset of mouse hippocampus profiled by LCMS MS for

Unsupervised machine learning using an imaging mass

Sep 13,2019 Dataset of mouse hippocampus profiled by LCMS MS for#0183;Data collection from rat brain sagittal sections using MALDI-FT-ICR-IMS.(A) Average mass spectrum of all measured points.The x-axis corresponds to the mass range between m/z 700 to 900,whereas the y-axis shows relative signal intensity.a.u.,arbitrary unit.(B) Lineup of all biomolecule distributions from a sagittal section of a rat brain in an IMS dataset,for which the number of Some results are removed in response to a notice of local law requirement.For more information,please see here.Previous123456NextDeep proteome profiling of the hippocampus in the 5XFAD Dataset of mouse hippocampus profiled by LCMS MS for#0183;Mass spectrometry-based proteomics.Mouse hippocampus tissues were resected and subjected to the previously described sample preparation methods with some modifications [18,19,20].Detailed procedures including protein digestion,peptide labeling,fractionation,and MS analysis are described in Additional file 1 Supplementary Methods.Some results are removed in response to a notice of local law requirement.For more information,please see here.12345NextJane ENGLISH Research Fellow PhD Royal College of This dataset reports on the analysis of mouse hippocampus by LCMS/MS,from mice fed a diet that was either deficient in n-3 FA (n-3 Def) or sufficient in n-3 FA (n-3 Adq).

Some results are removed in response to a notice of local law requirement.For more information,please see here.Sex differences in the molecular signature of the

A variety of neurological disorders,including Alzheimers disease,Parkinsons disease,major depressive disorder,dyslexia and autism,are differentially prevalent between females and males.To better understand the possible molecular basis for the sex-biased nature of neurological disorders,we used a developmental series of female and male mice at 1,2,and 4 months of age to assess Refinements of LC-MS/MS Spectral Counting Statistics Sep 20,2019 Dataset of mouse hippocampus profiled by LCMS MS for#0183;The statistical framework,automated spectral count refinement by integrating the two statistical tools,was tested with LC-MS/MS datasets of MDA

Quantitative proteomic analysis of mouse hippocampus in

Quantitative proteomic analysis was used to identify the proteins associated with a formation of fear memory in mice.The proteins from the hippocampal region were isolated from three groups of trained aminals representing aquisition,consolidation and retrieval of a contextual fear conditioning.The samples were digested by trypsin,analyzed by LC-MSMS followed by protein identification and Quantitative proteomic analysis of mouse hippocampus in Quantitative proteomic analysis was used to identify the proteins associated with a formation of fear memory in mice.The proteins from the hippocampal region were isolated from three groups of trained aminals representing aquisition,consolidation and retrieval of a contextual fear conditioning.The samples were digested by trypsin,analyzed by LC-MSMS followed by protein identification and Quantification of Neurotransmitters in Mouse Brain Tissue A simple and rapid liquid chromatography tandem mass spectrometry method has been developed for the determination of BH4,DA,5-HT,NE,EP,Glu,and GABA in mouse brain using epsilon-acetamidocaproic acid and isotopically labeled neurotransmitters as internal standards.Proteins in the samples were precipitated by adding acetonitrile,and then the supernatants were separated by a

PXD010986 - Proteomic profile of mouse hippocampus

Dataset Information.0.Proteomic profile of mouse hippocampus following kainate-induced epileptogenesis C4PR_LIV.Ontology highlight.ABSTRACT Anti-epileptogenic agents that prevent the development of epilepsy following a brain insult remain the holy grail of epilepsy therapeutics.In order to identify such drugs,it is necessary to first Jane ENGLISH Research Fellow PhD Royal College of This dataset reports on the analysis of mouse hippocampus by LCMS/MS,from mice fed a diet that was either deficient in n-3 FA (n-3 Def) or sufficient in n-3 FA (n-3 Adq).Indepth protein profiling of the postsynaptic density Sep 11,2014 Dataset of mouse hippocampus profiled by LCMS MS for#0183;Using ionmobility enhanced dataindependent labelfree LCMS/MS,we established a reference proteome of crude synaptosomes,synaptic junctions,and PSD derived from mouse hippocampus including TOP3based absolute quantification values for identified proteins.

Indepth protein profiling of the postsynaptic density

Sep 11,2014 Dataset of mouse hippocampus profiled by LCMS MS for#0183;Using ionmobility enhanced dataindependent labelfree LCMS/MS,we established a reference proteome of crude synaptosomes,synaptic junctions,and PSD derived from mouse hippocampus including TOP3based absolute quantification values for identified proteins.Indepth protein profiling of the postsynaptic density Nov 01,2014 Dataset of mouse hippocampus profiled by LCMS MS for#0183;Using ionmobility enhanced dataindependent labelfree LCMS/MS,we established a reference proteome of crude synaptosomes,synaptic junctions,and PSD derived from mouse hippocampus including TOP3based absolute quantification values for identified proteins.Indepth protein profiling of the postsynaptic density For LCMS analysis,the same subcellular fractionation protocol was used as described above to obtain synaptosomal membranes (P3).P3 was resuspended in 5 mM Tris/HCl,pH 8.1,and centrifuged in another sucrose density gradient (0.8/1.0/1.2 M) for 2 h at 85 000 Dataset of mouse hippocampus profiled by LCMS MS for#215; g for additional purification.Synaptic junctions (SJ) were collected from the 1.0/1.2 border,resuspended in Tris buffer

Hippocampus co-atrophy pattern in dementia deviates from

Introduction.The hippocampus is a notable brain region from its lifelong plasticity potential (Moreno-Jim Dataset of mouse hippocampus profiled by LCMS MS for#233;nez et al.,2019),which can be observed with microstructural and molecular investigations but also at the macrostructural level using morphological measurements of structural MRI.From macrostructural studies,the plasticity of the hippocampus seems to relate to experience and more HOST-MICROBE INTERACTIONS Copyright Dataset of mouse hippocampus profiled by LCMS MS for#169; 2020 AThe hippocampus exhibited the most sensitive response to probiotic treatment.The administration of heat-killed probiotics altered tandem MS (LC-MS/MS),including neuropeptides,peptide hormones,and other endogenous peptides.The high quality of quantitative dataset of C group,resulting in the identification of 2290,1162,1262,Deep proteome profiling of the hippocampus in the 5XFAD To understand the pathophysiology of the AD brain,the assessment of global proteomic dynamics is required.Since the hippocampus is a major region affected in the AD brain,we performed hippocampal analysis and identified proteins that are differentially expressed between wild-type and 5XFAD model mice via LC-MS methods.

Deep proteome profiling of the hippocampus in the 5XFAD

Nov 15,2019 Dataset of mouse hippocampus profiled by LCMS MS for#0183;Advances in liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) have enabled the high-throughput detection and quantification of thousands of proteins in numerous mouseDataset of mouse hippocampus profiled by LCMS/MSData Article Dataset of mouse hippocampus proled by LCMS/MS for label-free quantitation Jane A.Englisha,b,Caitriona Scaifeb,Akiko Haraumac,Melanie Fockinga,Kieran Wynneb,Gerard Cagneyb,Toru Moriguchic,David R.Cottera a Department of Psychiatry,Royal College of Surgeons in Ireland,ERC Beaumont Hospital,Dublin,Ireland b Proteome Research Centre,School of Medicine andDataset of mouse hippocampus profiled by LCMS/MS for Jun 01,2016 Dataset of mouse hippocampus profiled by LCMS MS for#0183;This dataset reports on the analysis of mouse hippocampus by LCMS/MS,from mice fed a diet that was either deficient in n-3 FA (n-3 Def) or sufficient in n-3 FA (n-3 Adq).Label free quantitative (LFQ) analysis of the mass spectrometry data identified 1008 quantifiable proteins,115 of which were found to be differentially expressed between

Dataset of mouse hippocampus profiled by LCMS/MS for

Dataset of mouse hippocampus profiled by LCMS/MS for Dataset of mouse hippocampus profiled by LC-MS/MS for This dataset reports on the analysis of mouse hippocampus by LC-MS/MS,from mice fed a diet that was either deficient in n-3 FA (n-3 Def) or sufficient in n-3 FA (n-3 Adq).Label free quantitative (LFQ) analysis of the mass spectrometry data identified 1008 quantifiable proteins,115 of which were fCited by 1Publish Year 2016Author Jane A.English,Caitriona Scaife,Akiko Harauma,Melanie Focking,Kieran Wynne,Gerard Cagney,Toru(PDF) Dataset of mouse hippocampus profiled by LC-MS/MS This dataset reports on the analysis of mouse hippocampus by LCMS/MS,from mice fed a diet that was either deficient in n-3 FA (n-3 Def) or sufficient in n-3 FA (n-3 Adq).

Circulating heparin oligosaccharides rapidly target the

May 07,2019 Dataset of mouse hippocampus profiled by LCMS MS for#0183;LC-MS (MRM) analysis procedure and results of 13 C-labeled heparan sulfate nonasaccharides are shown.( A ) GAGs recovery and LC-MS analysis flowchart for tissue samples.( B ) The change of amount (nanograms per milligram of dry-defatted tissue) of 13 C-labeled nonasaccharide in hippocampus at different time points.Age-related loss of neural stem cell O-GlcNAc promotes a Aug 25,2020 Dataset of mouse hippocampus profiled by LCMS MS for#0183;Depletion of the neural stem cell (NSC) pool is a major driver of age-related regenerative decline in the hippocampus.While increased quiescence is a major contributor to this decline,NSCs can also undergo terminal differentiation into astrocytes,thus restricting the stem cell pool.The mechanisms underlying this fate switch and their relation to age-related regenerative decline have not A dynamic mouse peptidome landscape reveals probiotic Jul 28,2020 Dataset of mouse hippocampus profiled by LCMS MS for#0183;Besides being a key player in the regulation of host metabolism and immunity,the gut microbiome also plays an important role in the gut-brain axis,a system of bidirectional communication between the central and enteric nervous systems.Zhang et al.analyzed the brain peptidomes and gut microbiomes of mice fed two different species of probiotics.Probiotic treatment altered the

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